Always keen on appearing in TV dramas in the Arab world, Dhafer starred in the TV series Eugénie Nights (2018), which takes place in Cairo and Port Said in 1946. In 2017, he starred in the two successful TV series Caramel and Halawat Al Dounia, for which he won the Murex D’or for Best Arab Actor in a TV series in 2018. L'Abidine starred in Al Khoroug TV series (2016), Taht Al Saytara TV series (2015), for which he won the Best Actor award at the Arab Satellite Channels Festival. He won critical acclaim for his performances in Farq Tawqeet (2014), Neran Sadeqa (2013), Vertigo (2012) and Zakerat Al Jassed (2010), which featured an array of A-list stars from across the region, and the Tunisian TV series Maktoub (2008).
As for Arab films, L'Abidine starred in several Tunisian films, including Dowaha (Buried Secrets) (2009), Fin December (2010), and Fausse Note (2012). And outside Tunisia, he starred in the Egyptian action-comedy film Esmat Abu Shanab (2016), the Lebanese film Habbet Caramel (2017), and El Ankabout (2019).
Dhafer is a UN Women’s champion and he works closely with the United Nation on the issues of gender equality and violence against women. In March 2018, Dhafer attended an event titled Understanding Masculinities in the Middle East and North Africa Region at the Japan Society in New York as a guest of honor. The event was organized by the UN Women, Brazilian organization Promundo, and the Swedish International Development Cooperation Agency (Sida).